In tumor tissues, SATB2 is detected in cancer cells of colorectal origin and may function as a clinically useful diagnostic marker for colorectal cancer (CRC).

SATB2 is a marker of osteoblastic differentiation in benign and malignant mesenchymal tumours. Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some settings, particularly in the distinction between hyalinized collagen and osteoid.

2005; Britanova et al. 2008). Se hela listan på academic.oup.com Special AT-rich sequence binding protein-2 (SATB2) is selectively expressed in the lower gastrointestinal tract mucosa and has been identified as a sensitive marker for colorectal adenocarcinomas. The goal of this study was to investigate the expression of SATB2 in well-differentiated neuroendocrine tumors to explore its potential as a diagnostic marker for hindgut well-differentiated 2017-10-01 · SATB2 was then identified as a potential immunohistochemical marker of human colorectal epithelium through screening of the Human Protein Atlas database by Magnusson et al. (3) The authors characterized the expression profile of SATB2 in normal human tissues using tissue microarrays, and found it to be highly expressed in the epithelium of the lower gastrointestinal tract (including appendix 2019-06-25 · Our study provides strong evidence that SATB2 is a better marker than CK20 for the distinction of ovarian mucinous neoplasms from colorectal carcinomas and we recommend replacement of CK20 by SATB2. The Role of SATB2 as a Diagnostic Marker for Tumors of Colorectal Origin Results of a Pathology-Based Clinical Prospective Study Anca Dragomir, MD, 2020-11-01 · SATB2 is now a commonly used immunohistochemical marker in surgical pathology, as a sensitive and specific marker for colorectal and appendiceal adenocarcinomas.

Satb2 marker

SATB2 in Human ortholog(s) of this gene implicated in SATB2-associated syndrome. Orthologous to Relationship, Marker Type, Marker, Accession Numbers, Citations 7 Feb 2008 Colocalization of Satb2 and the neuron-specific marker MAP2 demonstrated that Satb2+ cortical cells are postmitotic neurons (Figure 1E, insert). SATB2 is a new immunohistochemical marker with a few studies showing that it is specifically expressed in a large majority of colorectal adenocarcinomas. 28 Feb 2012 In the superficial layers of the CP, Satb2-positive cells were negative for the deep -layer marker Ctip2 in the WT (Fig. 2 D and E) (8), whereas in 29 Nov 2016 The genome-organizer Satb2 has a key role in memory formation by marker Wfs1 (Figure 1E) and the cortical layer markers Cux1, Ctip2, 15 Jun 2015 Our results indicate that SATB2 is a sensitive marker for hindgut well- differentiated neuroendocrine tumors though it is not entirely specific.

Diagnostic markers for well differentiated neuroendocrine tumors 7073 Int J Clin Exp Pathol 2015;8(6):7072-7082 Recently, special AT-rich se- quence binding protein-2 (SATB2) has been identified as a marker with a highly selective expression pattern in the lower gastrointestinal tract mucosa [11].

SATB2 is a biomarker for colorectal cancer, 85% of all CRC patients are positive for SATB2 and other cancer types rarely display SATB2 expression SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas (Am J Surg Pathol 2011;35:937)

SATB2 is a sensitive marker for lower gastrointestinal well-differentiated neuroendocrine tumors. Special AT-rich sequence binding protein-2 (SATB2) is selectively expressed in the lower gastrointestinal tract mucosa and has been identified as a sensitive marker for colorectal adenocarcinomas. SATB2 is a biomarker for colorectal cancer, 85% of all CRC patients are positive for SATB2 and other cancer types rarely display SATB2 expression SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas (Am J Surg Pathol 2011;35:937) SATB2 has been implicated as causative in the cleft or high palate of individuals with 2q32q33 microdeletion syndrome. SATB2 was found to be disrupted in two unrelated cases with de novo apparently balanced chromosome translocations associated with cleft palate and Pierre Robin sequence.

SATB2 is a novel, sensitive marker for colorectal carcinoma. We hypothesized that SATB2 IHC can reliably identify primary and metastatic signet ring cell carcinomas of lower GI tract origin.

Neurons in the upper cortical layers were defined by their immunoreactivity for Satb2+ (known to be expressed in L2, L3, L4, and L5; Fig. 2a–h) and Cux2 (normally expressed in L2 und L3, Fig. 2i–p) [12, 14–16, 20, 21]. SATB2 expression continued to mark the posterior intestinal endoderm throughout development (e11.5–e16.5) (Figures S1B, S1C, S1E, S1F, S1H, and S1J) and in the postnatal colon in mice (not shown) and humans (Figure S1L). In humans, GATA4 and SATB2 mark proximal and distal regions of the hu-man fetal and adult intestinal tract, respectively SATB2 induced malignant transformation and these transformed cells gained the characteristics of CSCs by expressing stem cell markers (CD44, CD133, LGR5 and DCLK1) and transcription factors (c-Myc positive for SATB2, and 2 SATB2–negative cases were positive for CDH-17. Therefore, CDH-17 and SATB2 are complementary and, when used together, could identify all MC.5 IV. Other markers available for detection of metastatic CRC Dragomir, et al reports that SATB2 marker alone had 93% sensitivity and 77% specificity in determining CRC. 26 Nov 2019 There is an unmet need for better markers of prognosis and treatment benefit for mCRC patients. The homeobox 2 gene SATB2 has a highly specific marker of the glandular epithelium lining the lower GI tract.

Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some settings, particularly in the distinction between hyalinized collagen and osteoid.
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IF: 2.0. A combination of the immunohistochemical markers CK7 and SATB2 is highly sensitive and specific for distinguishing primary ovarian Hälsa och samhälle PROGNOSTISK SIGNIFIKANS AV SATB1 OCH SATB2 is a correlation between the analyzed markers and that SATB1 expression is a av J Elebro · 2014 · Citerat av 43 — SwePub titelinformation: Prognostic and treatment predictive significance of SATB1 and SATB2 expression in pancreatic and periampullary adenocarcinoma. The role of SATB2 as a diagnostic marker for tumors of colorectal origin: Results of a pathology-based clinical prospective study.

3 The authors characterized the expression profile of SATB2 in normal human tissues using tissue microarrays, and found it to be highly expressed in the epithelium of the lower gastrointestinal tract (including appendix, colon, and … 2021-02-25 2020-09-11 2018-02-01 2008-02-07 SATB2 is a novel, sensitive marker for colorectal carcinoma. We hypothesized that SATB2 IHC can reliably identify primary and metastatic signet ring cell carcinomas of lower GI tract origin. SATB2 is a transcriptional regulator involved in osteoblastic and neuronal differentiation and is a sensitive and specific marker of colorectal epithelium. This study aimed to evaluate the expression of SATB2 in NNs from various primary sites and its utility as a marker in determining the site of origin of these neoplasms.
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Vanligen negativa: ER (9-30%), PGR (9-17%), SATB2 (9%), MUC5AC. Negativa: WT1, p16 (alt. MUC2 is a molecular marker for psudomyxoma peritonei. Mod. Intragenic duplication--a novel causative mechanism for SATB2-associated Inherited mosaicism for the supernumerary marker chromosome in cat eye Transcription factor programming of human ES cells generates functional neurons expressing both upper and deep layer cortical markers.

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2017-10-01 · SATB2 was then identified as a potential immunohistochemical marker of human colorectal epithelium through screening of the Human Protein Atlas database by Magnusson et al. (3) The authors characterized the expression profile of SATB2 in normal human tissues using tissue microarrays, and found it to be highly expressed in the epithelium of the lower gastrointestinal tract (including appendix

2013-05-23 Special AT-rich sequence binding protein-2 (SATB2) is selectively expressed in the lower gastrointestinal tract mucosa and has been identified as a sensitive marker for colorectal adenocarcinomas.